Search on: DNA-DEPENDENT DNA POLYMERASE II 
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Descriptor English:   DNA Polymerase II 
Descriptor Spanish:   ADN polimerasa II 
Descriptor Portuguese:   DNA Polimerase II 
Synonyms English:   DNA Dependent DNA Polymerase II
DNA Pol II
DNA Polymerase epsilon
DNA-Dependent DNA Polymerase II  
Tree Number:   D08.811.913.696.445.308.300.230
Definition English:   A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7. 
History Note English:   84(77); for DNA POLYMERASE EPSILON use DNA POLYMERASE II (NM) 1994-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   4324 
Unique Identifier:   D004257 

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